تأثیر مصرف کورکومین به همراه اکستازی بر افزایش سرکوب سیستم ایمنی ازنظر تولید آنتی‌بادی‌ها

Background & aims: Nowadays, one of the problems of the human society is drug addiction, which causes individual, economic, social and cultural damages. One of the most commonly used substances in circles and parties is ecstasy pills or 3,4-methylenedioxymethamphetamine (MDMA). These pills have severe damage to various systems of the body and brain. Therefore, in this study, we studied the anti- inflammatory effects of curcumin on reducing the complication of ecstasy on the immune system after taking these pills. Materials & Methods: In this experimental study 48 adult male wistar rats were divided into six groups: group1; control (received ethyl oleate 0.2 ml, IP, and 2 ml water in the form of oral for 15 days, without MDMA and Curcumin), group 2 (received MDMA 20 mg/kg in 2 ml distilted water in the form of oral and ethyl oleate 0.2 ml, IP, for 15 days), group 3 (received MDMA 20 mg/kg and injection of curcumin 20 µ mol/kg, IP, for 15 days), group 4 (received MDMA 20 mg/kg, for 15 days, then injection of ethyl oleate 0.2 ml, IP, and 2 ml water in the form of oral for 15 days), group 5 (received MDMA 20 mg/kg, for 15 days, then and injection of curcumin 20 µ mol/kg, IP, for 15 days), and group 6 (received MDMA 20 mg/kg and injection of curcumin 20 µ mol/kg, IP, for 15 days, then injection of curcumin 20 µ mol/kg, IP, for 15 days). The rats were anesthetized at the end of experiment. The blood samples were collected. Immunoglobulins of serum were measured.  Results: The results of this study showed that the using of MDMA with curcumin reduced serum immunoglobulin level in male wistar rats. This effect was significant in the MDMA group with curcumin compared to the control group (P˂0/05). But this reduction was not significant in the MDMA group alone (P>0/05).  Conclusion: The MDMA with curcumin, caused a significant reduction in serum immunoglobulin levels in male wistar rats. The reason for these significant changes compared to the control group and the group that only consumed MDMA was probably increased absorption and non-metabolizing of MDMA by curcumin, that from this finding, the specific characteristic of curcumin in modulating the immune system and main ting tolerance, can be used to induction tolerance in the use of some medications and food in the future.